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https://assobrafirciencia.org/article/doi/10.47066/2177-9333.AC.2020.0019
ASSOBRAFIR Ciência
Artigo de Revisão

Correlação entre a obesidade e o COVID-19: revisão integrativa

Luiz Fernando Isaias da Rocha, Arlete Ana Motter

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Resumo

Introdução: O surto da doença COVID-19, causada pelo novo coronavírus SARS-CoV-2, levou a OMS (Organização Mundial da Saúde) a declarar uma nova pandemia. Concomitante a esse cenário, encontramos a obesidade que se caracteriza como fator de risco para o COVID-19, sendo que o vírus utiliza o tecido adiposo como reservatório primário para o aumento da carga viral integral. Objetivo: Portanto, essa revisão tem por objetivo reunir e sintetizar informações proveniente dos artigos analisados sobre a relação entre obesidade e COVID-19 e ressaltar a importância da prevenção do COVID-19 nesse grupo e as possíveis lacunas encontradas sobre o tema. Métodos: A coleta de dados foi realizada na PubMed em dezembro de 2020. Além disso, foram incluídos artigos em inglês, espanhol e português, limitando a pesquisa a ensaios clínicos, meta-análises e revisões sistemáticas, do período de 2020 a 2021, utilizando-se as seguintes palavras chaves: “Obesity AND SARS-Cov-2 OR obesity AND Covid-19”. Resultados: Foram incluídos 19 artigos nessa revisão integrativa. O número de pacientes obesos foi observado em 11 artigos, correspondendo a aproximadamente 31% do total de participantes. A maior parte dos pacientes eram do sexo masculino e acima de 60 anos. Conclusão: Por fim, observou-se que a obesidade mostra-se ligada ao prognóstico grave do COVID-19, bem como pacientes obesos com o coronavírus SARS-CoV-2 têm maior risco de serem hospitalizados, admitidos em uma unidades de terapia intensiva (UTI), necessitarem do uso de ventilação mecânica invasiva (VMI) e irem a óbito.

Palavras-chave

Obesidade, COVID-19, SARS-COV-2.

Referências

1. Cucinotta D, Vanelli M. WHO declares Covid-19 a pandemic. Acta Biomed. 2020;91(1):157-60. PMid:32191675.

2. de Souza CDF, de Paiva JPS, Leal TC, da Silva LF, Santos LG, de Souza CDF, et al. Spatiotemporal evolution of case fatality rates of COVID-19 in Brazil. J Bras Pneumol. [Internet]. 2020 [citado em 2020 Dez 27];46(4):e20200208. Disponível em: http:// www.scielo.br/scielo.php?script=sci_abstract&pid=S1806- 37132020000401001&lng=en&nrm=iso&tlng=en

3. Nguyen HA. Vitamina D, obesidade e COVID-19: a gap. USA: Authorea; 2020.

4. WHO: World Health Organization. Modes of transmission of virus causing COVID-19: implications for IPC precaution recommendations: scientific brief [Internet]. Geneva: WHO; 2020 [citado em 2021 Dez 27]. Disponível em: https://apps. who.int/iris/handle/10665/331616

5. Kruglikov IL, Shah M, Scherer PE. Obesity and diabetes as comorbidities for COVID-19: underlying mechanisms and the role of viral–bacterial interactions. Elife. 2020;9:e61330. http://dx.doi.org/10.7554/eLife.61330. PMID: 32930095.

6. Morais AHA. Passos TS, Vale SHL, Maia JKS, Maciel BLL. Obesity and the increased risk for COVID-19: mechanisms and nutritional management. Nutrition Research Reviews. First View , 1-13.

7. Brandão SCS, Godoi ETA, Cordeiro LHO, Bezerra CS, Ramos JOX, de Arruda GFA,  et  al. Obesidade e risco de Covid-19: grave [Internet]. Recife: A Autora; 2020. [citado 2020 Dez 27]. Disponível em: https://repositorio.ufpe.br/ handle/123456789/37572

8. Najafabadi MG, Khah AS, Rostad M. Sedentary lifestyle among office workers and coronary heart disease risk factors due to the COVID-19 quarantine. Work. 2020;67(2):281-3.

9. Feiz Arefi M, Babaei-Pouya A, Poursadeqiyan M. The health effects of quarantine during the COVID-19 pandemic. Work. 2020;67(3):523-7. http://dx.doi.org/10.3233/WOR-203306. PMid:33164969.

10. Moazzami B, Chaichian S, Kasaeian A, Djalalinia S, Akhlaghdoust M, Eslami M, et al. Metabolic risk factors and risk of Covid-19: A systematic review and meta-analysis. PLoS One. 2020;15(12):e0243600. http://dx.doi.org/10.1371/ journal.pone.0243600. PMid:33320875.

11. Pantea Stoian A, Pricop-Jeckstadt M, Pana A, Ileanu B-V, Schitea R, Geanta M,  et  al. Death by SARS-CoV 2: a Romanian COVID-19 multi-centre comorbidity study. Sci Rep. 2020;10(1):21613. http://dx.doi.org/10.1038/s41598- 020-78575-w. PMid:33303885.

12. Chu Y, Yang J, Shi J, Zhang P, Wang X. Obesity is associated with increased severity of disease in COVID-19 pneumonia: a systematic review and meta-analysis. Eur J Med Res. 2020;25(1):64. http://dx.doi.org/10.1186/s40001-020-00464- 9. PMid:33267871.

13. Földi M, Farkas N, Kiss S, Dembrovszky F, Szakács Z, Balaskó M,  et  al. Visceral adiposity elevates the risk of critical condition in covid-19: a systematic review and meta-analysis. Obesity (Silver Spring). 2021;29(3):521-8. http://dx.doi. org/10.1002/oby.23096. PMid:33263191.

14. Yang J, Tian C, Chen Y, Zhu C, Chi H, Li J. Obesity aggravates COVID-19: an updated systematic review and meta-analysis. J Med Virol. 2021 maio;93(5):2662-74. PMid:33200825.

15. Mesas AE, Cavero-Redondo I, Álvarez-Bueno C, Sarriá Cabrera MA, Maffei de Andrade S, Sequí-Dominguez I,  et  al. Predictors of in-hospital COVID-19 mortality: a comprehensive systematic review and meta-analysis exploring differences by age, sex and health conditions. PLoS One. 2020;15(11):e0241742. http://dx.doi.org/10.1371/ journal.pone.0241742. PMid:33141836.

16. Soeroto AY, Soetedjo NN, Purwiga A, Santoso P, Kulsum ID, Suryadinata H,  et  al. Effect of increased BMI and obesity on the outcome of COVID-19 adult patients: a systematic review and meta-analysis. Diabetes Metab Syndr. 2020;14(6):1897-904. http://dx.doi.org/10.1016/j. dsx.2020.09.029. PMid:33007661.

17. Huang Y, Lu Y, Huang Y-M, Wang M, Ling W, Sui Y, et al. Obesity in patients with COVID-19: a systematic review and meta-analysis. Metabolism. 2020;113:154378. http://dx.doi. org/10.1016/j.metabol.2020.154378. PMid:33002478.

18. Malik P, Patel U, Patel K, Martin M, Shah C, Mehta D, et al. Obesity a predictor of outcomes of COVID-19 hospitalized patients– A systematic review and meta-analysis. J Med Virol. 2021;93(2):1188-93. http://dx.doi.org/10.1002/jmv.26555. PMid:32975814.

19. Chang T-H, Chou C-C, Chang L-Y. Effect of obesity and body mass index on coronavirus disease 2019 severity: a systematic review and meta-analysis. Obes Rev. 2020;21(11):e13089. http://dx.doi.org/10.1111/obr.13089. PMid:32929833.

20. Peres KC, Riera R, Martimbianco ALC, Ward LS, Cunha LL. Body mass index and prognosis of covid-19 infection. A systematic review. Front Endocrinol (Lausanne). 2020;11:562. http://dx.doi.org/10.3389/fendo.2020.00562. PMid:32922366.

21. Seidu S, Gillies C, Zaccardi F, Kunutsor SK, Hartmann-Boyce J, Yates T, et al. The impact of obesity on severe disease and mortality in people with SARS-CoV-2: a systematic review and meta-analysis. Endocrinol Diabetes Metab. 2020;24(1):e00176. https://doi.org/10.1002/edm2.176.

22. Sharma A, Garg A, Rout A, Lavie CJ. Association of obesity with more critical illness in Covid-19. Mayo Clin Proc. 2020;95(9):2040-2. http://dx.doi.org/10.1016/j. mayocp.2020.06.046. PMid:32861346.

23. Sales-Peres SHC, de Azevedo-Silva LJ, Bonato RCS, SalesPeres MC, Pinto ACDS, Santiago Junior JF. Coronavirus (SARSCoV-2) and the risk of obesity for critically illness and ICU admitted: meta-analysis of the epidemiological evidence. Obes Res Clin Pract. 2020 set-out;14(5):389-97. http://dx.doi. org/10.1016/j.orcp.2020.07.007. PMid:32773297.

24. de Siqueira JVV, Almeida LG, Zica BO, Brum IB, Barceló A, de Siqueira Galil AG. Impact of obesity on hospitalizations and mortality, due to COVID-19: a systematic review. Obes Res Clin Pract. 2020;14(5):398-403. http://dx.doi.org/10.1016/j. orcp.2020.07.005. PMid:32736969.

25. Zhou Y, Yang Q, Chi J, Dong B, Lv W, Shen L,  et  al. Comorbidities and the risk of severe or fatal outcomes associated with coronavirus disease 2019: a systematic review and meta-analysis. Int J Infect Dis. 2020;99:47-56. http://dx.doi.org/10.1016/j.ijid.2020.07.029. PMid:32721533.

26. Malik VS, Ravindra K, Attri SV, Bhadada SK, Singh M. Higher body mass index is an important risk factor in COVID-19 patients: a systematic review and meta-analysis. Environ Sci Pollut Res Int. 2020;27(33):42115-23. http://dx.doi. org/10.1007/s11356-020-10132-4.

27. Földi M, Farkas N, Kiss S, Zádori N, Váncsa S, Szakó L, et al. Obesity is a risk factor for developing critical condition in COVID-19 patients: a systematic review and meta-analysis. Obes Rev. 2020;21(10):e13095. http://dx.doi.org/10.1111/ obr.13095. PMid:32686331.

28. Tamara A, Tahapary DL. Obesity as a predictor for a poor prognosis of COVID-19: a systematic review. Diabetes Metab Syndr. 2020;14(4):655-9. http://dx.doi.org/10.1016/j. dsx.2020.05.020. PMid:32438328.

29. Yang J, Ma Z, Lei Y. A meta-analysis of the association between obesity and COVID-19. Epidemiology & Infection. 2021;149:E11. http://dx.doi.org/10.1017/ S0950268820003027.

30. Kass DA, Duggal P, Cingolani O. Obesity could shift severe COVID-19 disease to younger ages. Lancet. 2020;395(10236):1544-5. http://dx.doi.org/10.1016/S0140- 6736(20)31024-2. PMid:32380044.

31. Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with covid-19 in the new york city area. JAMA. 2020;323(20):2052-9. http://dx.doi.org/10.1001/ jama.2020.6775. PMid:32320003.

32. Bolsoni-Lopes A, Furieri L, Alonso-Vale MIC. Obesidade e a covid-19: uma reflexão sobre a relação entre as pandemias. Rev Gaúcha Enferm. [Internet]. 2021 [citado em 2021 Mar 8];42(1). Disponível em: https://www.seer.ufrgs.br/ RevistaGauchadeEnfermagem/article/view/110507

33. Rocha GV, Soares CEM, Oliveira LH Fo, do Amaral MVF, de Castro VE, Antonacci E Jr, et al. A influência da obesidade na mortalidade de adultos com COVID-19. Braz J Health Rev. 2021;4(1):1405-18. http://dx.doi.org/10.34119/ bjhrv4n1-119.

34. Borges JFT, Rebelo AAF, Spinasse GS, Santos JR No, Massoud ABP, Miranda GF, et al. A obesidade como fator de risco no pior prognóstico do Covid-19: uma revisão integrativa. Braz J Health Rev. 2021;4(1):3699-712. http://dx.doi.org/10.34119/ bjhrv4n1-292.

35. Jordão MRZ, Ribeiro JN, Gimenes C, Pessoa BV, Jamami M, Martinelli B. Obesidade abdominal e o sistema respiratório. Fisioter Bras. 2018;19(6):850-6. http://dx.doi.org/10.33233/ fb.v19i6.1664.

36. Mohammad S, Aziz R, Al Mahri S, Malik SS, Haji E, Khan AH, et al. Obesity and COVID-19: what makes obese host so vulnerable? Immun Ageing. 2021;18(1):1. http://dx.doi. org/10.1186/s12979-020-00212-x. PMid:33390183.


Submetido em:
19/03/2021

Aceito em:
06/06/2021

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