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Efeitos do exercício físico realizado acima do limiar de lactato sobre a função ventricular de ratos portadores de insuficiência cardíaca

Effects of exercise performed above lactate threshold on ventricular function in rats with heart failure

Rafael Michel de Macedo, Ana Carolina Brandt de Macedo, José Rocha Faria Neto, Julio Cesar Francisco, Ricardo Cunha, Luiz Cesar Guarita-Souza

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Resumo

Introdução: Os efeitos provocados pelo treinamento físico de alta intensidade, sob a função ventricular na insuficiência cardíaca, ainda, são controversos. Objetivo: Avaliar o efeito provocado pelo exercício físico realizado acima do limiar de lactato na função ventricular de ratos portadores de insuficiência cardíaca de etiologia isquêmica. Métodos: Vinte ratos machos Wistar foram infartados em laboratório, mediante técnica de ligadura de coronária esquerda. Foram incluídos no estudo, 10 animais com fração de ejeção do ventrículo esquerdo (FEVE) ≤ 50% (avaliados por ecocardiografia, 30 dias após o infarto). Estes foram randomizados em dois grupos: Grupo Controle (GC) (n=5) e Grupo Treinamento (GT) (n=5). O segundo foi submetido a três sessões semanais de natação, com uma duração de 15 minutos cada, com intensidade de nado mantida acima do limiar de lactato, durante quatro semanas (12 sessões de treinamento). Para controle da intensidade de treino, foi coletada uma amostra de sangue da cauda do animal, para mensuração do lactato sanguíneo acumulado. Como medidas de desfecho, foram comparadas intra, intergrupos as variáveis FEVE, o volume diastólico final do ventrículo esquerdo (VDFVE) e o volume sistólico final do ventrículo esquerdo (VSFVE). Resultados: pré- treinamento: GC x GT- FEVE (%) (35,20±7,64 vs 21,49± 2,71, p=0,004), VSFVE (ml) (0,39±0,15 vs 0,50±0,09 p=0,05), VDFVE (ml) (0,89±0,19 vs 0,7 ±0,14, p=0,26).Pós-treinamento: FEVE (%) (22,39±4,56 vs 20,71±7,41, p=0,73), VSFVE (ml) (0,65±0,12 vs 0,64 ±0,05, p=0,92), VDFVE (0,83±0,13 vs 0,82±0,09, p=0,91). Conclusão: O exercício de alta intensidade provocou aumento do VSFVE e do VDFVE

Palavras-chave

Terapia por Exercício; Insuficiência Cardíaca; Remodelamento Ventricular

Abstract

The effects of high-intensity exercise training on the cardiac remodeling are still unknown. Objective: To assess the effects of physical exercise performed above the lactate threshold on ventricular function of rats with heart failure. Methods: 20 male Wistar rats were infarcted in the laboratory by the technique of left coronary artery ligation. Of these 10 were included in the study by presenting 30 days after acute myocardial infarction, with left ventricle ejection fraction (LVEF) ≤ 50%. The animals were randomized into two groups: control group (CG) (n=5) and trained group (TG) (n=5). The second was submitted to 3 sessions / week of swimming with 15 minutes of duration, with intensity above the lactate threshold, during 4 weeks (i.e 12 training sessions). The control of training intensity was done checking a blood sample collected from the animal tail for measurement of blood lactate. Intra and inter-group differences of the variables LVEF, left ventricle final systole volume (LVFSV) and left ventricle final diastole volume (LVFDV) were compared. Results: Pre training: trained x sedentary respectively, LVEF (%) (35.20 ± 7.64 vs 21.49 ± 2.71, p=0.004), LVFSV (ml) (0.39 ± 0.15 vs 0, 50 ± 0.09, p=0.05), LVEDV (ml) (0.89 ± 0.19 vs 0.7 ± 0.14, p= 0.26). Post training: LVEF (%) (22, 39 ± 4.56 vs 20.71 ± 7.41, p=0.73), LVFSV (ml) (0.65 ± 0.12 vs 0.64 ± 0.05, p=0.92) LVEDV (0.83 ± 0.13 vs 0.82 ± 0.09, p=0.91). Conclusion: The high-intensity exercise increased LVFSV and LVFDV

Keywords

Exercise Therapy; Heart Failure; Ventricular Remodeling.

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